The Sinister Six was an alliance of villains sharing one common goal: revenge on Spider-Man. Initially led by Doctor Octopus, the group's lineup consisted of Venom, Kraven the Hunter, Black Cat, Green Goblin and Electro – who had all been soundly defeated by Spider-Man. Doctor Octopus assured his comrades that by working together, they could finally destroy the web-slinger for their mutual benefit.