In an effort to reverse his on-going mutation, the amazing Spider-Man took an experimental serum created by Dr. Mariah Crawford. But the serum backfired, causing Spider-Man to mutate even faster, transforming him into the six-armed, inhuman Man-Spider! It took the combined might of the Punisher and Kraven the Hunter to stop Man-Spider, and the scientific brilliance of Dr. Crawford to turn him back to Spider-Man!
